At the interface of stress and immune tolerance.
A new category of medicine.
Over the last 100 years, our most valuable medicines for autoimmune disorders have been derived from insights of stress signals emitted by the central nervous system— corticosteroids, epinephrine, thyroid hormone, and catecholamines are all potent immunomodulatory drugs that have given physicians the ability to reign in autoimmune diseases.
To further expand the capabilities of medicine for autoimmune disorders, Serenity is focusing on the communication network between the central nervous system and macrophages. Macrophages are a key type of immune cell that plays significant roles in autoimmune diseases, and serves as a unique starting point to potentially address unmet needs for lupus, graft-versus-host-disease, and many other severe conditions.
SerenityBio has identified key receptors on macrophages that potently modulate macrophage activity, and has successfully demonstrated that targeting these receptors avoid pro-inflammatory responses initiated by innate receptors or the inflammasome.