At the interface of stress and immune tolerance.
A new category of medicine.
Over the last 100 years, our most valuable medicines for autoimmune disorders have been derived from insights of physiological stress — cortisone, prednisone, epinephrine, thyroid hormone, and catecholamines are all potent immunomodulatory drugs that have given physicians the ability to reign in autoimmune diseases.
To further expand the capabilities of medicine for autoimmune disorders, Serenity is focusing on cellular stress pathways. When cells encounter a stressful environment — whether it be a lack of oxygen, increase in temperature, or exposure to a toxin — they express a myriad of stress-induced proteins, like heat shock proteins (HSPs), to maintain the cell’s order. In some instances, cells also secrete and export these signals to communicate with immune cells to avoid cellular destruction and inflammation, and maintain self-antigen tolerance. The benefits of exercise, sauna-use, and fevers, have all pointed towards stress-induced signals that can be used to treat diseases.
Recent academic research in stress, genomics, proteomics, and systems immunology has given us the tools for novel therapeutic development. Serenity is using these tools to develop a pipeline of new medicines that will address urgent unmet needs for autoimmune disorders.